I wanna see a fic with a squib protagonist that rises to power by using potions and alchemy to permanently alter their body and imbue it with effects and powers to overcome their disadvantage against conventional witches and wizards. Borrow the magic resistance from giants, the speed from werewolves, the durability from vampires. Imbue yourself with permanent versions of pepper up, wit sharpening, and healing potions. Give yourself the holy grail and combine alchemy with Felix Felicis to make yourself permanently, unnaturally lucky (though maybe the effect is reduced.) Strengthen your bones, enhance muscles and healing, make yourself immune to poisons and acids. *Turn yourself into the Terminator. *
There would always be some new thing that witches and wizards could throw at you, but every new trick only works once.